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Anti-aging drugs are being tested as a way to treat covid

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Anti-aging drugs are being tested as a way to treat covid


Mannick has been exploring the effects of rapamycin-like drugs in covid-19. Her trial has been taking place in nursing homes experiencing outbreaks of the disease. For four weeks, half the participants were given the drug, while the other half were given a placebo. Among those given a placebo, “25% of them developed severe covid, and half of them died,” says Mannick, who has yet to publish the work. None of those taking the drug developed any covid-19 symptoms.

“There are multiple strategies of helping the aging immune system to fight against covid better,” she says. “Aging is the biggest risk factor for severe covid, and it’s a modifiable risk factor.”

She hopes to extend the use of her drug beyond covid-19; a rejuvenated immune system could theoretically fend off many other viral and bacterial infections. Her colleague Stanley Perlman, a coronavirologist at the University of Iowa who coauthored the research on BioAge’s covid drug in mice, has future pandemics in mind. “Next time there’s another coronavirus in 2030, maybe all this information will be very useful then,” he says.

Out with the old

The immune system isn’t the only target of anti-aging drugs. Others aim to clear out aged cells. Most of the cells in our body divide up to a certain point. Once they reach this limit, they should die and be cleared away by the immune system. But that’s not always the case—some cells linger on. These cells no longer divide, and some instead churn out a toxic brew of chemicals that trigger damaging inflammation in the surrounding area and beyond. 

Cells that do this are called “senescent,” and they accumulate across our organs as we age. They’ve been linked to an ever-growing number of age-related diseases, including diabetes, heart disease, osteoporosis, cataracts, Alzheimer’s—the list goes on. They also appear to play an important role in coronavirus infections.

In yet-to-be-published research, James Kirkland, who studies aging and cell senescence at the Mayo Clinic in Rochester, Minnesota, says he has evidence that coronavirus more rapidly infects senescent cells than non-senescent cells. His research also suggests that senescent cells release chemicals that make neighboring non-senescent cells take up the virus too, he says.

Not only do these cells take on more coronavirus, but they also appear to provide a breeding ground for new virus variants. “There’s emerging evidence that senescent cells that are infected with coronavirus can mutate that virus,” says Kirkland. “So they may even be a cause of viral mutations.”

As an added concern, the coronavirus can make healthy cells senescent. Given all this, senescence has become an obvious target of both anti-aging and covid-19 therapies. Studies in mice and hamsters suggest that compounds that kill senescent cells can improve the symptoms of covid-19 and boost the chances of survival.

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The Download: a curb on climate action, and post-Roe period tracking

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The US Supreme Court just gutted federal climate policy


Why’s it so controversial?: Geoengineering was long a taboo topic among scientists, and some argue it should remain one. There are questions about its potential environmental side effects, and concerns that the impacts will be felt unevenly across the globe. Some feel it’s too dangerous to ever try or even to investigate, arguing that just talking about the possibility could weaken the need to address the underlying causes of climate change.

But it’s going ahead?: Despite the concerns, as the threat of climate change grows and major nations fail to make rapid progress on emissions, growing numbers of experts are seriously exploring the potential effects of these approaches. Read the full story.

—James Temple

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 The belief that AI is alive refuses to die
People want to believe the models are sentient, even when their creators deny it. (Reuters)
+ It’s unsurprising wild religious beliefs find a home in Silicon Valley. (Vox)
+ AI systems are being trained twice as quickly as they were just last year. (Spectrum IEEE)

2 The FBI added the missing cryptoqueen to its most-wanted list
It’s offering a $100,000 reward for information leading to Ruja Ignatova, whose crypto scheme defrauded victims out of more than $4 billion. (BBC)
+ A new documentary on the crypto Ponzi scheme is in the works. (Variety)

3 Social media platforms turn a blind eye to dodgy telehealth ads
Which has played a part in the prescription drugs abuse boom. (Protocol)
+ The doctor will Zoom you now. (MIT Technology Review)

4 We’re addicted to China’s lithium batteries
Which isn’t great news for other countries building electric cars. (Wired $)
+ This battery uses a new anode that lasts 20 times longer than lithium. (Spectrum IEEE)
+ Quantum batteries could, in theory, allow us to drive a million miles between charges. (The Next Web)

5 Far-right extremists are communicating over radio to avoid detection
Making it harder to monitor them and their violent activities. (Slate $)
+ Many of the rioters who stormed the Capitol were carrying radio equipment. (The Guardian)

6 Bro culture has no place in space 🚀
So says NASA’s former deputy administrator, who’s sick and tired of misogyny in the sector. (CNN)

7 A US crypto exchange is gaining traction in Venezuela
It’s helping its growing community battle hyperinflation, but isn’t as decentralized as they believe it to be. (Rest of World)
+ The vast majority of NFT players won’t be around in a decade. (Vox)
+ Exchange Coinbase is working with ICE to track and identify crypto users. (The Intercept)
+ If RadioShack’s edgy tweets shock you, don’t forget it’s a crypto firm now. (NY Mag)

8 It’s time we learned to love our swamps
Draining them prevents them from absorbing CO2 and filtering out our waste. (New Yorker $)
+ The architect making friends with flooding. (MIT Technology Review) 

9 Robots love drawing too 🖍️
Though I’ll bet they don’t get as frustrated as we do when they mess up. (Input)

10 The risky world of teenage brains
Making potentially dangerous decisions is an important part of adolescence, and our brains reflect that. (Knowable Magazine)

Quote of the day

“They shamelessly celebrate an all-inclusive pool party while we can’t even pay our rent!”

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The US government is developing a solar geoengineering research plan

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The US government is developing a solar geoengineering research plan


The move, which has not been previously reported on, marks the first federally coordinated US effort of this kind. It could set the stage for more funding and research into the feasibility, benefits, and risks of such interventions. The effort may also contribute to the perception that geoengineering is an appropriate and important area of research as global temperatures rise.

Solar geoengineering encompasses a range of different approaches. The one that’s gained the most attention is using planes or balloons to disperse tiny particles in the stratosphere. These would then—in theory—reflect back enough sunlight to ease warming, mimicking the effect of massive volcanic eruptions in the past. Some research groups have also explored whether releasing certain particles could break up cirrus clouds, which trap heat against the Earth, or make low-lying marine clouds more reflective.

The 2022 federal appropriations act, signed by President Biden in March, directs his Office of Science and Technology Policy to develop a cross-agency group to coordinate research on such climate interventions, in partnership with NASA, the National Oceanic and Atmospheric Administration (NOAA), and the Department of Energy. 

The measure calls for the group to create a research framework to “provide guidance on transparency, engagement, and risk management for publicly funded work in solar geoengineering research.” Specifically, it directs NOAA to support the Office of Science and Technology Policy in developing a five-year plan that will, among other things, define research goals for the field, assess the potential hazards of such climate interventions, and evaluate the level of federal investments required to carry out that work. 

Geoengineering was long a taboo topic among scientists, and some argue it should remain one. There are questions about potential environmental side effects, and concerns that the impacts will be felt unevenly in different parts of the globe. It’s not clear how the world will grapple with tricky questions regarding global governance, including who should make decisions about whether to deploy such powerful tools and what global average temperatures we should aim for. Some feel that geoengineering is too dangerous to ever try or even to investigate, arguing that just talking about the possibility could make the need to address the underlying causes of climate change feel less urgent.

But as the threat of climate change grows and major nations fail to make rapid progress on emissions, more researchers, universities, and nations are seriously exploring the potential effects of these approaches. A handful of prominent scientific groups, in turn, have called for stricter standards to guide that work, more money to do it, or both. That includes the National Academies of Sciences, Engineering, and Medicine, which last year recommended setting up a US solar geoengineering research program with an initial investment of $100 million to $200 million over five years. 

Proponents of geoengineering research, while stressing that cutting emissions must remain the highest priority, say we should explore these possibilities because they may meaningfully reduce the dangers of climate change. They note that as heat waves, droughts, famines, wildfires, and other extreme events become more common or severe, these sorts of climate interventions may be among the few means available to rapidly ease widespread human suffering or ecological calamities. 

Setting standards

In a statement, the Office of Science and Technology Policy confirmed that it has created an interagency working group, as called for under the federal funding bill. It includes representatives of 10 research and mission agencies, including NOAA, NASA, and the Department of Energy.  

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How to track your period safely post-Roe

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How to track your period safely post-Roe


Why use a period tracker?

Stress or dietary changes, among other factors, can make periods irregular and unpredictable. Tracking them can help expose underlying health issues, such as fibroids, which are noncancerous uterine growths. It can also help people spot patterns in mood and energy, which can often be affected by ovulation. People trying to get pregnant often use period trackers to figure out when they’re most fertile. 

So why are people panicking?

The overturning of Roe v. Wade in the US triggered laws that made abortion illegal in 13 states, and more states are likely to ban abortion in the coming months. In states that have banned abortions, people could now be prosecuted if they are alleged to have had one. The worry is that their digital data footprint could be used to build such a case. Missing your period is not a crime, but evidence of it could be subpoenaed and used to bolster a case against someone suspected of an abortion. 

What do companies that make period-tracking apps have to say about this?

We reached out to some of the major period-tracking apps—Flo, Clue, and SpotOn (an app from Planned Parenthood)—for comment on what their privacy settings are and whether they would turn information over to authorities in states where abortion is illegal. Clue and SpotOn did not respond, though Clue stated on Twitter that because it is based in the European Union, it is not permitted to share data with authorities in the US: 

“We would have a primary legal duty under European law not to disclose any private health data. We repeat: we would not respond to any disclosure request or attempted subpoena of our users’ health data by US authorities. But we would let you and the world know if they tried.”

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