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Liquid Biopsy Identifies Who Can Skip Chemo After Colon Cancer Surgery: Study

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Liquid Biopsy Identifies Who Can Skip Chemo After Colon Cancer Surgery: Study


The following are summaries of some of the cancer research advances being presented the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

Liquid biopsy shows who can skip chemotherapy after colon surgery

Liquid biopsy can help identify patients with stage II colon cancer who do not need chemotherapy to prevent recurrence after surgery, according to results of a 455-patient study presented on Saturday.

Among patients in the study who were tested via liquid biopsy, 15% ended up receiving chemotherapy versus 28% whose risk was determined using standard diagnostics. Two years later, rates of survival without recurrence were similar, at roughly 93%, in both groups, the researchers reported at ASCO 2022 and in The New England Journal of Medicine.

Very few patients with these cancers – which have grown through the colon wall but not reached the lymph nodes – will actually benefit from adjuvant, or post-surgery, chemotherapy. But “every patient struggles with the question of whether to skip it,” especially those considered at low or intermediate risk of recurrence based on surgeons’ observations or analysis of the excised tumor, said study leader Dr. Jeanne Tie of the Peter MacCallum Cancer Centre in Melbourne, Australia.

Most vulnerable to recurrence are patients with hard-to-find cancer cells remaining after surgery. Those cells shed genetic material into the blood that can be picked up by liquid biopsies. In the study, doctors determined which patients should receive chemotherapy in one group based on whether tumor genetic material was seen in liquid biopsies. That was compared with another group whose chemotherapy decision was determined by traditional clinical risk factors.

Chemotherapy is physically and financially toxic, Tie said. With this approach, “we are selecting the right people to treat,” she said. “Patients are so relieved when we tell them they don’t need chemotherapy.”

Acetaminophen interferes with cancer immunotherapy

The popular painkiller and fever reducer acetaminophen interferes with a widely-used class of cancer immunotherapies, known as immune checkpoint inhibitors (ICI), significantly limiting their affect, according to a study that will be presented at the ASCO meeting on Monday.

Drugs in the ICI class include Merck & Co’s Keytruda, Opdivo and Yervoy from Bristol Myers Squibb Co and Roche’s Tecentriq.

“This study provides strong… evidence” that acetaminophen has the potential to suppress the effects of ICIs and “should be used with caution” in patients receiving these drugs, the French researchers said.

Their study looked at patients with advanced cancers receiving immunotherapy drugs. In those taking acetaminophen for pain, as determined by evidence of it in their blood, tumor response to the cancer drugs was significantly poorer than in patients not taking acetaminophen, they found. Patients using acetaminophen, also known as paracetamol, also had faster progression of their disease and earlier death, although those differences were not statistically significant.

In experiments in animals and in blood samples from healthy volunteers, acetaminophen “significantly limited the effect” of the cancer immunotherapies, the researchers said.

The study was also being published this week in Annals of Oncology.

Osteoporosis drug tied to lasting benefit in breast cancer

Hormone therapy for breast cancer in postmenopausal women impairs bone health and increases fracture risk, but Amgen Inc’s osteoporosis drug Prolia given twice-a-year not only counteracted those effects but was associated with significantly slower disease progression and improved survival in a years-long, large study.

In the study of nearly 3,500 postmenopausal women receiving aromatase inhibitors for their breast cancer, such as Arimidex from AstraZeneca and Femara from Novartis, patients received either a Prolia injection every six months or a placebo. Prolia, a monoclonal antibody known chemically as denosumab, curbs the bone thinning seen with osteoporosis.

With half of the study participants followed for at least eight years, women in the Prolia group had a 24% lower risk of fracture, a 17% lower risk of cancer progression, a 19% lower risk of bone marrow problems, and a 26% improvement in survival compared to women in the placebo group, without any adverse effects of the treatment, according to data scheduled for presentation on Tuesday at ASCO 2022.

Giving Prolia every six months “should be considered for routine clinical use” in postmenopausal patients receiving aromatase inhibitors for breast cancer, the researchers said.





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Feeling Tired All The Time? Possible Causes And Solutions

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Long days of work, lack of sleep, and stress at the office can be the most common factors that make you feel tired. However, feeling “tired all the time” (TATT) without known reasons can be an indication of an underlying health issue that needs immediate attention.

Finding the exact cause of the lingering tiredness can be the first step toward solving the symptom.

Health conditions that cause fatigue:

1. Anemia – Anemia is one of the most common causes of fatigue. A person who has anemia does not have enough red blood cells in the body, causing symptoms such as tiredness, dizziness, feeling cold and crankiness.

Most often, anemia is caused by iron deficiency. Hence, the condition can be best resolved by including iron-rich foods in the diet and use of iron supplements.

2. Sleep Apnea – It causes the body to stop breathing momentarily during sleep. The condition can affect the quality of sleep and hence make you feel fatigued.

For milder cases of sleep apnea, lifestyle changes such as losing weight or quitting smoking can help solve the sleep disorder. In more severe cases where there is an obstruction in breathing, surgeries and therapies can help.

3. Diabetes – A person who has diabetes has changes in blood sugar level, which can cause fatigue. A patient who is already on diabetic medication can also experience tiredness as a side effect of the medication.

Early identification and taking the correct treatment is the key to managing diabetes. Losing extra weight and having a healthy diet also help in the treatment.

4. Thyroid – Thyroid diseases can be due to an overactive or an underactive thyroid gland. In people who have an underactive thyroid (hypothyroidism), the metabolism slows down leading to symptoms such as lethargy and fatigue. In people with an overactive thyroid (hyperthyroidism), the metabolism speeds up leading to fatigue and difficulty sleeping.

Right diet and lifestyle choices, along with medications, can help in thyroid management.

5. Infections – A person can show symptoms of fatigue when the body is fighting a viral or bacterial infection. Infections ranging from the flu to HIV can cause tiredness.

Along with fatigue, other symptoms such as fever, headache, body aches, shortness of breath and appetite loss can also accompany the infection. Treating the symptoms and taking adequate rest helps in faster recovery.

6. Food allergies – Fatigue may be an early warning sign of hidden food allergies and autoimmune disorders such as celiac disease. Identifying the allergen using a food allergy test or through an elimination diet can help in allergy treatment.

7. Heart disease – If you feel exhausted from an activity that used to be easy, then it is good to check your heart health, as fatigue can be an indication of underlying heart disease.

8. Depression/ anxiety – Fatigue can also be an indicator of a mental health disorder such as depression or anxiety. A combination of medication and psychotherapy can help relieve symptoms.

Lifestyle causes

Apart from serious health conditions, certain lifestyle habits such as dehydration, poor diet, stress and insufficient sleep can cause exhaustion. Having a well-balanced diet, regular exercise and routine sleep can help solve fatigue caused by lifestyle habits.

Published by Medicaldaily.com



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How To Overcome Your Sleep Debt And Reclaim Energy

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Picture this: you’re burning the midnight oil, studying or binge-watching your favorite shows, all at the expense of a good night’s sleep. Have you ever stopped to think about the toll it takes on your body and mind? The consequences can be more serious than you might realize.

Not getting enough sleep can translate into a multitude of issues, including weight gain, lack of focus, tiredness, a haze of confusion, and even depression. If you too are encountering similar issues lately then chances are you have a sleep debt.

Wondering what is sleep debt?

People from 13-18 years of age need 8 hours of sleep, whilst adults beyond that age will require at least 7 hours of snooze.

Sleep debt is a collection of the total hours you haven’t slept or traded your sleep for something else. Sleep debt keeps piling up as a person falls short of the total hours of sleep recommended for an adult, according to the Centers for Disease Control and Prevention.

And when you keep letting go of your sleep for other activities, the body adapts to the new normal and effects start to reflect on the energy levels, which deplete.

“However, like every other debt out there, this too has a repayment option,” Dr. Kunal Kumar, medical director of the Sleep Center at Einstein Medical Center in Philadelphia, told Livestrong.

Below are some expert-vetted ways you can pay back the sleep debt. (Courtesy: Livestrong and Sleepfoundation)

Just like financial debt, imagine sleep debt as a debt you owe to your body. It needs to be repaid. The good news is that catching up on sleep is indeed possible.

  • Maintain a set sleep schedule: Overhauling the sleep schedule is a pretty difficult task to achieve, and it’s best to do that gradually. Create a set sleep schedule by making some small changes to your routine. Instead of making abrupt shifts in your bedtime or wake-up time, adjust them gradually by 15 to 30-minute increments.
  • Minimize your gadget usage: Wind down activities and minimize electronic usage before bed to promote better sleep. Relax and prepare for quality sleep by dimming the lights and setting an alarm for 30 minutes to an hour before bed.
  • Reshuffle your sleeping arrangements: Are you finding it hard to get a good night’s sleep due to excessive sweating? Well, here’s a handy solution: consider upgrading to a cooling mattress or opting for cooling sheets. These innovative sleep essentials can help regulate your body temperature, and keep you comfortably cool throughout the night, ensuring a more blissful slumber. Memory foam pillows can work wonders in relieving neck and back discomfort in case you are struggling with backache.
  • Improve the bedroom environment: Create a sleep-friendly bedroom environment by adjusting the temperature for comfort, and blocking out disruptive lights, or noises that might disturb your restful slumber. And if your mattress, pillow, or sheets are worn out or no longer providing the support you need, consider treating yourself to new ones.

Published by Medicaldaily.com



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Omega-3 Fatty Acids Slow The Progression Of Amyotrophic Lateral Sclerosis: Study

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Omega-3 fatty acids are known for a range of health benefits, from promoting brain and heart health to reducing inflammation and protection against several chronic conditions.

In a new study, researchers found that omega-3 acids, especially the type found in foods like flaxseeds, walnuts, chia seeds, canola oil and soybean oil, can slow down the progression of amyotrophic lateral sclerosis (ALS).

It is a debilitating nervous system disease that gradually worsens over time and can be fatal. The condition results in a loss of muscle control and affects the nerve cells in the brain and spinal cord. It is also known as Lou Gehrig’s disease after the baseball player who was diagnosed with it.

The initial symptoms of the disease include muscle weakness, difficulty in walking and hand movements. The symptoms can slowly progress to difficulties with chewing, swallowing, speaking and breathing.

The exact cause of ALS is not known. However, around 10% of people get it from a risk gene passed down from a family member. It is estimated that more than 32,000 people in the U.S. live with the condition.

In the latest study, researchers from Harvard T.H. Chan School of Public Health in Massachusetts evaluated 449 people living with ALS in a clinical trial. The team assessed the severity of their symptoms, the progression of their disease, along with the levels of omega-3 fatty acids in their blood, for 18 months.

The study suggested that alpha-linolenic acid (ALA), a type of omega-3 found in plants, is particularly beneficial in slowing the progression of ALS. The participants with the highest levels of ALA had a 50% reduced risk of death during the study period compared to those with the lowest levels of ALA.

Researchers also found a reduction in death risk in participants who had eicosapentaenoic acid, the type of omega-3 fatty acid found in fatty fish and fish oil, and linoleic acid found in vegetable oils, nuts and seeds.

A previous study conducted by the same team suggested that a diet high in ALA and higher blood levels of the nutrient could reduce the risk of developing the condition.

“In this study, we found that among people living with ALS, higher blood levels of ALA were also associated with a slower disease progression and a lower risk of death within the study period. These findings, along with our previous research suggest that this fatty acid may have neuroprotective effects that could benefit people with ALS,” said Kjetil Bjornevik, the lead author of the study.

Published by Medicaldaily.com



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