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Study Reveals Alarming Mortality Rates For COVID-Associated Fungal Infections

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Fungal infections become more deadly when COVID-19 is involved, according to research.

A recent study conducted by the Centers for Disease Control and Prevention (CDC) has uncovered alarming mortality rates among patients hospitalized for COVID-associated fungal infections. The data showed a significant disparity when compared to fungal infections unrelated to the virus during the pandemic era.

The study, led by Dr. Jeremy Gold and his team at the CDC in Atlanta, shed light on the severity of the issue.

Between 2020 and 2021, the mortality rate for in-hospital COVID-associated fungal infections stood at a staggering 48.5%. In contrast, the mortality rate for non-COVID-associated fungal infections was 12.3%.

The researchers highlighted specific fungal infections linked to COVID-19 that exhibited the highest mortality rates, including aspergillosis (57.6%), invasive candidiasis (55.4%), mucormycosis (44.7%) and unspecified mycoses (59.0%).

These findings aligned with previously reported data, which also indicated higher COVID-associated deaths involving Candida and Aspergillus, according to MedPage Today.

Dr. Gold and his colleagues emphasized the importance of maintaining a high level of clinical suspicion for fungal infections in high-risk patients, particularly those with COVID-19. The study underscored the need for enhanced surveillance of fungal diseases to detect emerging trends and guide appropriate interventions.

The study analyzed a total of 59,212 fungal infection hospitalizations spanning from 2019 to 2021. Rates per 10,000 hospitalizations showed an increase from 22.3 in 2019 to 25.0 in 2020 and further to 26.8 in 2021. The average annual percentage change in the rates was calculated to be 8.5%.

From 2020 to 2021, 13.4% of the 39,423 fungal hospitalizations were associated with COVID. The rates of COVID-associated fungal hospitalizations per 10,000 COVID hospitalizations rose by 24.9%.

The hospitalizations resulted in longer stays, with a median duration of 21 days compared to 9 days for non-COVID-associated fungal infections. They were also more likely to involve intensive care and patients with COVID-associated fungal infections had a higher likelihood of requiring invasive mechanical ventilation.

Additionally, the study revealed demographic disparities, with COVID-associated fungal infections being more prevalent in men and Hispanic/Latino individuals. The infections were also more likely to occur in western states.

The researchers noted that racial or ethnic disparities could be linked to long-standing inequities in social health determinants, limited access to medical care, occupational exposures, and higher prevalence of underlying conditions such as diabetes, which increase the risk of fungal and COVID-19 infections among certain minority groups.

The study authors also acknowledged the potential role of immune system therapies in the observed trends. COVID-19 infection was identified as a significant risk factor for certain fungal infections, particularly those caused by invasive molds. This association was likely due to COVID-19-related immune system dysregulation and the use of immunosuppressive therapies like corticosteroids or other immunomodulatory medications.

The researchers utilized the Premier Healthcare Database, Special COVID-19 Release, a comprehensive hospital-based, all-payer database employed by the CDC for COVID response activities. Hospitalizations involving fungal infections and COVID were identified between January 2019 and December 2021. The median age of patients hospitalized for COVID-associated fungal infections was 63, compared to 61 for those with non-COVID-associated fungal infections.

The authors acknowledged some limitations, including potential underreporting, misclassification, and nonspecific coding of pathogenic fungi due to fungal diagnosis codes. Furthermore, they highlighted the lack of comprehensive data on fungal infections during the pandemic in the United States, as many fungal diseases are not currently reportable.

Published by Medicaldaily.com



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Feeling Tired All The Time? Possible Causes And Solutions

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Long days of work, lack of sleep, and stress at the office can be the most common factors that make you feel tired. However, feeling “tired all the time” (TATT) without known reasons can be an indication of an underlying health issue that needs immediate attention.

Finding the exact cause of the lingering tiredness can be the first step toward solving the symptom.

Health conditions that cause fatigue:

1. Anemia – Anemia is one of the most common causes of fatigue. A person who has anemia does not have enough red blood cells in the body, causing symptoms such as tiredness, dizziness, feeling cold and crankiness.

Most often, anemia is caused by iron deficiency. Hence, the condition can be best resolved by including iron-rich foods in the diet and use of iron supplements.

2. Sleep Apnea – It causes the body to stop breathing momentarily during sleep. The condition can affect the quality of sleep and hence make you feel fatigued.

For milder cases of sleep apnea, lifestyle changes such as losing weight or quitting smoking can help solve the sleep disorder. In more severe cases where there is an obstruction in breathing, surgeries and therapies can help.

3. Diabetes – A person who has diabetes has changes in blood sugar level, which can cause fatigue. A patient who is already on diabetic medication can also experience tiredness as a side effect of the medication.

Early identification and taking the correct treatment is the key to managing diabetes. Losing extra weight and having a healthy diet also help in the treatment.

4. Thyroid – Thyroid diseases can be due to an overactive or an underactive thyroid gland. In people who have an underactive thyroid (hypothyroidism), the metabolism slows down leading to symptoms such as lethargy and fatigue. In people with an overactive thyroid (hyperthyroidism), the metabolism speeds up leading to fatigue and difficulty sleeping.

Right diet and lifestyle choices, along with medications, can help in thyroid management.

5. Infections – A person can show symptoms of fatigue when the body is fighting a viral or bacterial infection. Infections ranging from the flu to HIV can cause tiredness.

Along with fatigue, other symptoms such as fever, headache, body aches, shortness of breath and appetite loss can also accompany the infection. Treating the symptoms and taking adequate rest helps in faster recovery.

6. Food allergies – Fatigue may be an early warning sign of hidden food allergies and autoimmune disorders such as celiac disease. Identifying the allergen using a food allergy test or through an elimination diet can help in allergy treatment.

7. Heart disease – If you feel exhausted from an activity that used to be easy, then it is good to check your heart health, as fatigue can be an indication of underlying heart disease.

8. Depression/ anxiety – Fatigue can also be an indicator of a mental health disorder such as depression or anxiety. A combination of medication and psychotherapy can help relieve symptoms.

Lifestyle causes

Apart from serious health conditions, certain lifestyle habits such as dehydration, poor diet, stress and insufficient sleep can cause exhaustion. Having a well-balanced diet, regular exercise and routine sleep can help solve fatigue caused by lifestyle habits.

Published by Medicaldaily.com



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How To Overcome Your Sleep Debt And Reclaim Energy

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Picture this: you’re burning the midnight oil, studying or binge-watching your favorite shows, all at the expense of a good night’s sleep. Have you ever stopped to think about the toll it takes on your body and mind? The consequences can be more serious than you might realize.

Not getting enough sleep can translate into a multitude of issues, including weight gain, lack of focus, tiredness, a haze of confusion, and even depression. If you too are encountering similar issues lately then chances are you have a sleep debt.

Wondering what is sleep debt?

People from 13-18 years of age need 8 hours of sleep, whilst adults beyond that age will require at least 7 hours of snooze.

Sleep debt is a collection of the total hours you haven’t slept or traded your sleep for something else. Sleep debt keeps piling up as a person falls short of the total hours of sleep recommended for an adult, according to the Centers for Disease Control and Prevention.

And when you keep letting go of your sleep for other activities, the body adapts to the new normal and effects start to reflect on the energy levels, which deplete.

“However, like every other debt out there, this too has a repayment option,” Dr. Kunal Kumar, medical director of the Sleep Center at Einstein Medical Center in Philadelphia, told Livestrong.

Below are some expert-vetted ways you can pay back the sleep debt. (Courtesy: Livestrong and Sleepfoundation)

Just like financial debt, imagine sleep debt as a debt you owe to your body. It needs to be repaid. The good news is that catching up on sleep is indeed possible.

  • Maintain a set sleep schedule: Overhauling the sleep schedule is a pretty difficult task to achieve, and it’s best to do that gradually. Create a set sleep schedule by making some small changes to your routine. Instead of making abrupt shifts in your bedtime or wake-up time, adjust them gradually by 15 to 30-minute increments.
  • Minimize your gadget usage: Wind down activities and minimize electronic usage before bed to promote better sleep. Relax and prepare for quality sleep by dimming the lights and setting an alarm for 30 minutes to an hour before bed.
  • Reshuffle your sleeping arrangements: Are you finding it hard to get a good night’s sleep due to excessive sweating? Well, here’s a handy solution: consider upgrading to a cooling mattress or opting for cooling sheets. These innovative sleep essentials can help regulate your body temperature, and keep you comfortably cool throughout the night, ensuring a more blissful slumber. Memory foam pillows can work wonders in relieving neck and back discomfort in case you are struggling with backache.
  • Improve the bedroom environment: Create a sleep-friendly bedroom environment by adjusting the temperature for comfort, and blocking out disruptive lights, or noises that might disturb your restful slumber. And if your mattress, pillow, or sheets are worn out or no longer providing the support you need, consider treating yourself to new ones.

Published by Medicaldaily.com



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Omega-3 Fatty Acids Slow The Progression Of Amyotrophic Lateral Sclerosis: Study

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Omega-3 fatty acids are known for a range of health benefits, from promoting brain and heart health to reducing inflammation and protection against several chronic conditions.

In a new study, researchers found that omega-3 acids, especially the type found in foods like flaxseeds, walnuts, chia seeds, canola oil and soybean oil, can slow down the progression of amyotrophic lateral sclerosis (ALS).

It is a debilitating nervous system disease that gradually worsens over time and can be fatal. The condition results in a loss of muscle control and affects the nerve cells in the brain and spinal cord. It is also known as Lou Gehrig’s disease after the baseball player who was diagnosed with it.

The initial symptoms of the disease include muscle weakness, difficulty in walking and hand movements. The symptoms can slowly progress to difficulties with chewing, swallowing, speaking and breathing.

The exact cause of ALS is not known. However, around 10% of people get it from a risk gene passed down from a family member. It is estimated that more than 32,000 people in the U.S. live with the condition.

In the latest study, researchers from Harvard T.H. Chan School of Public Health in Massachusetts evaluated 449 people living with ALS in a clinical trial. The team assessed the severity of their symptoms, the progression of their disease, along with the levels of omega-3 fatty acids in their blood, for 18 months.

The study suggested that alpha-linolenic acid (ALA), a type of omega-3 found in plants, is particularly beneficial in slowing the progression of ALS. The participants with the highest levels of ALA had a 50% reduced risk of death during the study period compared to those with the lowest levels of ALA.

Researchers also found a reduction in death risk in participants who had eicosapentaenoic acid, the type of omega-3 fatty acid found in fatty fish and fish oil, and linoleic acid found in vegetable oils, nuts and seeds.

A previous study conducted by the same team suggested that a diet high in ALA and higher blood levels of the nutrient could reduce the risk of developing the condition.

“In this study, we found that among people living with ALS, higher blood levels of ALA were also associated with a slower disease progression and a lower risk of death within the study period. These findings, along with our previous research suggest that this fatty acid may have neuroprotective effects that could benefit people with ALS,” said Kjetil Bjornevik, the lead author of the study.

Published by Medicaldaily.com



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