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Weight Loss Surgery Saves Lives, 40-Year Study Finds

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Weight Loss Surgery Saves Lives, 40-Year Study Finds


Weight loss surgery saves and extends the lives of patients, according to a new study that took 40 years to complete. 

Published in the journal Obesity on Wednesday, the study focused on the all-cause and cause-specific mortality for bariatric surgery procedures. 

The long-term study had 21,837 participants who had weight loss surgery in Utah. Follow-up on the patients spanned up to 40 years. 

The team found that weight loss surgery reduced the risk of premature death from obesity-related conditions, including cancer, diabetes and heart disease. 

According to the researchers, people who had one of the four types of weight loss surgery procedures (gastric bypass, gastric banding, gastric sleeve and duodenal switch) were found to be 16% less likely to die from any cause compared with those of similar weight who did not undergo surgery. 

For both females and males, a significant drop in mortality rate was observed after bariatric surgery. To be exact, the mortality rates for cardiovascular disease, cancer and diabetes dropped by 29%, 43% and 72%, respectively.

“Deaths from cardiovascular disease decreased by 29%, while deaths from various cancers decreased by 43%, which is pretty impressive,” lead author Ted Adams said, as quoted by CNN

Adams is an adjunct associate professor in nutrition and integrative physiology at the University of Utah’s School of Medicine. 

He continued, “There was also a huge percentage drop — a 72% decline — in deaths related to diabetes in people who had surgery compared to those who did not.”

However, the findings in the study were not limited to the positive effects of the weight loss procedures on the mortality rate of the participants. 

One downside that the scientists observed was younger people (18-34) who had weight loss surgery had a higher risk for suicide than those who did not have surgery. 

“Rate of death from suicide was significantly higher in surgery versus non-surgery participants only in the youngest age at surgery participants,” the team wrote.

The authors hope their findings could help address the suicide rates in the younger age group by inspiring more aggressive pre-surgical psychological screening and post-surgery follow-up. 

A previous study from Sweden published in 2013 presented similar findings to the new study. The older research, which spanned ten years, reported significant reductions in premature deaths after bariatric surgery.





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Scientists Suggest Simple Supplement To Combat Key Protein That Drives Aging

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Scientists Suggest Simple Supplement To Combat Key Protein That Drives Aging


People are always trying out different techniques and supplements to combat aging signs. A new study has now suggested that a simple supplement could potentially accelerate anti-aging in humans.

The study, published in the journal PLOS Biology, found loss of a protein called Menin could be responsible for the aging process, and a dietary supplement of D-serine could reverse it in mice.

The study focused on hypothalamic Menin. The hypothalamus is part of the brain that acts as a mediator of physiological aging. It does so by increasing neuroinflammatory signaling over time. Further, inflammation encourages multiple age-related processes, both in the brain and the periphery.

“We speculate that the decline of Menin expression in the hypothalamus with age may be one of the driving factors of aging, and Menin may be the key protein connecting the genetic, inflammatory, and metabolic factors of aging. D-serine is a potentially promising therapeutic for cognitive decline,” Lige Leng of Xiamen University, Xiamen, China, and study author, said, SciTechDaily reported.

For the study, researchers created conditional knockout mice, which have reduced Menin activity. Reduction of Menin in younger mice increased hypothalamic neuroinflammation as well as aging-related phenotypes, such as reductions in bone mass and skin thickness, cognitive decline, and modestly reduced lifespan, the study found.

Moreover, loss of Menin was also found to induce a decline in levels of the amino acid D-serine. A neurotransmitter, D-serine is found in soybeans, eggs, fish, and nuts, and is also available as a dietary supplement. According to researchers, the downslide in the production of the amino acid was due to the loss of activity of an enzyme involved in its synthesis (which was in turn regulated by Menin).

In the experiment, the study authors delivered the gene for Menin into the hypothalamus of elderly (20-month-old) mice. It was found 30 days later that the mice showed improved skin thickness, bone mass, learning, cognition, and balance, which was in tandem with an increase in D-serine within the hippocampus–a region of the brain critical for learning and memory.

Similar benefits on cognition, not including the peripheral signs of aging, could be observed by undergoing three weeks of dietary supplementation with D-serine, as per the outlet.

“Ventromedial hypothalamus (VMH) Menin signaling diminished in aged mice, which contributes to systemic aging phenotypes and cognitive deficits. The effects of Menin on aging are mediated by neuroinflammatory changes and metabolic pathway signaling, accompanied by serine deficiency in VMH, while restoration of Menin in VMH reversed aging-related phenotypes,” Leng explained.

While on the topic of anti-aging, a drug prescribed for the treatment of type 2 diabetes is being used off-label as an anti-aging medication. Metformin belongs to a class of drugs called biguanides. However, there are no proven studies to support these claims.





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Healthy Pets And Hospitalized Humans May Transmit Drug-Resistant Microbes To Each Other, Study Shows

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LA Offers Free COVID-19 Testing For Pets Exposed To Virus


A new, revealing study has found healthy dogs and cats can transmit multidrug-resistant organisms to their hospitalized owners and vice versa.

The study is being presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases in Copenhagen, Denmark.

Led by Dr. Carolin Hackmann from Charité University Hospital Berlin, Germany, the study enrolled more than 2,800 hospital patients and their pets to test their hypothesis.

“Our findings verify that the sharing of multidrug-resistant organisms between companion animals and their owners is possible,” said Dr. Hackmann, SciTechDaily reported. “However, we identified only a handful of cases suggesting that neither cat nor dog ownership is an important risk factor for multidrug-resistant organism colonization in hospital patients.”

Antimicrobial resistance refers to the increased resilience of infection-causing microbes to the drugs used to kill them. As per the outlet, antimicrobial-resistant infections were responsible for more than 1.3 million deaths, and were connected to 5 million deaths across the globe in 2019.

For the study, researchers focused on the most common superbugs found in hospital patients–methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, 3rd generation cephalosporin-resistant Enterobacterales and carbapenem-resistant Enterobacterales.

Called multidrug-resistant organisms (MDROs), these bacteria are resistant to treatment with more than one antibiotic.

In the study, nasal and rectal swabs were collected from around 3000 patients hospitalized in Charité University Hospital, Berlin, as well as from any dogs and cats that lived in their households.

The presence of the type of bacteria was identified by genetic sequencing.

Following analysis, it was found 30% of hospital patients tested positive for MDROs, and 70% tested negative. Furthermore, among those who tested MDRO-positive, the rate of dog ownership and cat ownership was 11% and 9% respectively. The figure was 13% in MDRO-negatives.

Moreover, all pet owners were requested to collect and send throat and stool swab samples of their pets. And 300 pet owners sent back samples from 400 pets. It was found 15% of dogs and 5% of cats tested positive for at least one MDRO.

“Although the level of sharing between hospital patients and their pets in our study is very low, carriers can shed bacteria into their environment for months, and they can be a source of infection for other more vulnerable people in the hospital such as those with a weak immune system and the very young or old,” Dr. Hackmann concluded, according to The Guardian.

In other news, an animal shelter in Luzerne County, Pennsylvania, has temporarily shut down after dozens of dogs contracted canine influenza.

“A few of our dogs started to get diarrhea, but that’s pretty normal for dogs that are in a new stressful environment. When our longer-term dogs started to get diarrhea and started not wanting to eat, we realized they weren’t themselves, that’s when we knew something was wrong,” shelter volunteer Emma Ripka said.





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What is ‘Harvard Diet’? 6 Eating Practices For Optimal Health

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Can Healthy People Who Eat Right And Exercise Skip The COVID-19 Vaccine?


Not many people know about the Harvard diet, which has been created as an eating guide for optimal health.

Also called the healthy eating plate, the Harvard diet was conceptualized in 2011. For formulating the ultimate diet plan, experts at the Harvard T.H. Chan School of Public Health worked in collaboration with researchers from Harvard Health Publications.

“In terms of major chronic diseases like prevention of cardiovascular disease, different types of cancers [and] Type 2 diabetes, this way of eating is going to be helpful to prevent those diseases that are common in America, and the world,” said Lilian Cheung, lecturer of nutrition at Harvard’s school of public health, CNBC reported.

The Healthy Eating Plate can be used as a guide for “creating healthy, balanced meals—whether served at the table or packed in a lunch box” as per Harvard’s website.

Here are the six pointers to follow the Harvard diet

Vegetables and fruits–half of the plate

Fruits and vegetables should make up half of a person’s plate. Researchers suggest aiming “for color and variety” as well as eating vegetables more than fruits.

Also, be careful what constitutes a vegetable. For instance, “a potato is not a vegetable from a nutrition point of view,” Cheung explained. “Potatoes almost behave like a refined carbohydrate. It increases your blood sugar.”

The nutrition expert also recommended consuming whole fruits over juices.

Whole grains–a quarter of the plate

The diet plan encourages eating whole grains and not refined grains.

“Whole grains have much more vitamins and also phytochemicals and minerals, which is much healthier for us and won’t raise [our] blood sugar so fast,” Cheung said, according to the news outlet.

A few options to consider include oats, quinoa, barley, whole wheat, and brown rice.

Protein–a quarter of the plate

The healthy eating plate suggests the type of proteins to consume, and the ones to ignore.

Healthy proteins like fish, chicken, beans, nuts, and duck should make up a quarter of your plate. 

Avoid red meat and steer clear of processed meats like bacon and sausage, Cheung suggested.

Plant oils–in moderation

The Harvard diet asks to avoid trans fats such as partially hydrogenated oils like margarine and certain vegetable oils. Healthier options include oils made from olive, canola, soy, corn, sunflower, and peanut (if not allergic).

Drink water, tea, or coffee

“We were really deliberate in terms of the drinks,” says Cheung. 

“We didn’t think that it was the most prudent way to go about it, especially because there are some populations in the U.S. that are lactose intolerant,” said Cheung of the notion that people should drink three cups of milk each day.

“Even with just the amount of calories from drinking [milk] that way, it would be more preferable to be drinking water, tea, or coffee,” Cheung further said.

The diet recommends drinking water, tea, and coffee alternatively with one’s meals, while also keeping sugar in the beverages little to none.

Stay active

The eating plan is incomplete without physical activity. “We need to be engaging [for] half an hour a day, or at least five times a week, in vigorous activity,” Cheung noted.

“We’re all aging, and we should form good habits while we are young,” Cheung continued, “so they become part of our habit and our routine.”





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