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What’s The Best COVID-19 Vaccine Booster For Janssen Recipients?

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What’s The Best COVID-19 Vaccine Booster For Janssen Recipients?


Now that booster doses are rolling out in the country, many people are skeptical about getting additional shots that are different from the main COVID-19 vaccine they had. This is particularly true for those who got the Johnson & Johnson vaccine. But there is evidence that Janssen recipients will actually benefit more from getting Moderna or Pfizer booster doses than the one being offered by J&J and BioNTech.

Janssen Vs. Moderna and Pfizer Vaccines

Before delving deeper into the mixing and matching of vaccines and boosters, it is important to first understand the difference between the Janssen vaccine and the vaccines from Pfizer and Moderna. Janssen is a type of carrier vaccine wherein a harmless adenovirus is engineered to deliver genetic code for spike proteins that will train the body’s immune system on how to respond to an actual SARS-CoV-2 infection. 

Unlike the J&J vaccine, the Pfizer and Moderna vaccines are classified as mRNA vaccines. This means that the other two vaccines deliver genetic codes from the SARS-CoV-2 virus itself to the human body, so that cells could make copies of spike proteins that would stimulate an immune response should the recipient be exposed to the actual coronavirus, as explained by Yale Medicine

J&J’s vaccine was designed to be a single-dose biological preparation, whereas Moderna’s and Pfizer’s vaccines were made to be two-dose preparations. Due to their different formulations, the three vaccines available in the country also have varying efficacy. A comparative report released by the Centers for Disease Control and Prevention (CDC) in September showed that the Moderna vaccine provided 93% protection to adults without underlying conditions, while Pfizer recorded 88% and Janssen reported 71%.

Efficacy Of Janssen Booster

In October, J&J’s vaccine booster was officially given authorization by the U.S. Food and Drug Administration for emergency use. This would mean that those who got their Janssen doses at least two months prior could now get their second dose that’s expected to amplify their immune protection against the novel coronavirus amid the ongoing pandemic. 

Prior to the authorization, J&J issued a statement saying that based on its clinical trials, the second Janssen dose does reinforce protection from COVID-19. From the data it collected in the course of the trials, the pharmaceutical company found that the booster offered 100% protection against severe infection and 95% against symptomatic infection in U.S. recipients. The Janssen booster also reportedly produced four to six times higher antibody levels than the main dose if the interval between the two was at least two months. On the other hand, there was a 12-fold increase in antibodies if the interval was at six months. 

Mixing and Matching Vaccine Boosters

The FDA and CDC recently recommended the mixing and matching of booster doses among the three brands. What this means is that those who got the Pfizer vaccine can get a booster from Moderna and J&J if the one from Pfizer is not readily accessible to them. The same is true for the other two brands. But considering the variation in the vaccine formulations, many are skeptical about getting a different booster from their main vaccine. 

Experts have shared their views on the issue, and most of them said that Janssen recipients could actually benefit more if they were to get their booster from either Moderna or Pfizer. Among them is Donald Alcendor, PhD, an assistant professor of Cancer Biology at Meharry Medical College and adjunct associate professor of Cancer Biology at Vanderbilt University School of Medicine. 

“Evidence also suggests that there is a more robust immune response when the second dose for a single-shot J&J vaccine is Moderna or Pfizer-BioNTech. This provides a growing body of evidence that supports the notion that mixing and matching of the J&J vaccine is warranted due the stronger immune response induced by the Pfizer or Modern vaccines as the second component to the J&J single dose,” Alcendor told Contagion

A study published in medRxiv last month determined the difference in efficacy between homologous and heterologous booster vaccinations using the three vaccine brands. For homologous vaccination (same vaccine and booster), the resulting neutralizing antibody titers increased 4.2-20-fold. On the other hand, for heterogenous vaccination (different vaccine and booster), the titers increased 6.2-76-fold. The findings suggest that getting a different booster for Janssen recipients would lead to a much better outcome.

“I’ve seen the data, and I would hope the (FDA) and the CDC are also impressed with the data. Clearly, if you’ve received the J&J dose and then you received one of the mRNA vaccines, you get a very large boost in antibody—even more antibody than if you got a second dose of J&J,” Vanderbilt University Medical Center Professor of Preventive Medicine William Schaffner, MD, who was not involved in the study, said.





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Feeling Tired All The Time? Possible Causes And Solutions

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Long days of work, lack of sleep, and stress at the office can be the most common factors that make you feel tired. However, feeling “tired all the time” (TATT) without known reasons can be an indication of an underlying health issue that needs immediate attention.

Finding the exact cause of the lingering tiredness can be the first step toward solving the symptom.

Health conditions that cause fatigue:

1. Anemia – Anemia is one of the most common causes of fatigue. A person who has anemia does not have enough red blood cells in the body, causing symptoms such as tiredness, dizziness, feeling cold and crankiness.

Most often, anemia is caused by iron deficiency. Hence, the condition can be best resolved by including iron-rich foods in the diet and use of iron supplements.

2. Sleep Apnea – It causes the body to stop breathing momentarily during sleep. The condition can affect the quality of sleep and hence make you feel fatigued.

For milder cases of sleep apnea, lifestyle changes such as losing weight or quitting smoking can help solve the sleep disorder. In more severe cases where there is an obstruction in breathing, surgeries and therapies can help.

3. Diabetes – A person who has diabetes has changes in blood sugar level, which can cause fatigue. A patient who is already on diabetic medication can also experience tiredness as a side effect of the medication.

Early identification and taking the correct treatment is the key to managing diabetes. Losing extra weight and having a healthy diet also help in the treatment.

4. Thyroid – Thyroid diseases can be due to an overactive or an underactive thyroid gland. In people who have an underactive thyroid (hypothyroidism), the metabolism slows down leading to symptoms such as lethargy and fatigue. In people with an overactive thyroid (hyperthyroidism), the metabolism speeds up leading to fatigue and difficulty sleeping.

Right diet and lifestyle choices, along with medications, can help in thyroid management.

5. Infections – A person can show symptoms of fatigue when the body is fighting a viral or bacterial infection. Infections ranging from the flu to HIV can cause tiredness.

Along with fatigue, other symptoms such as fever, headache, body aches, shortness of breath and appetite loss can also accompany the infection. Treating the symptoms and taking adequate rest helps in faster recovery.

6. Food allergies – Fatigue may be an early warning sign of hidden food allergies and autoimmune disorders such as celiac disease. Identifying the allergen using a food allergy test or through an elimination diet can help in allergy treatment.

7. Heart disease – If you feel exhausted from an activity that used to be easy, then it is good to check your heart health, as fatigue can be an indication of underlying heart disease.

8. Depression/ anxiety – Fatigue can also be an indicator of a mental health disorder such as depression or anxiety. A combination of medication and psychotherapy can help relieve symptoms.

Lifestyle causes

Apart from serious health conditions, certain lifestyle habits such as dehydration, poor diet, stress and insufficient sleep can cause exhaustion. Having a well-balanced diet, regular exercise and routine sleep can help solve fatigue caused by lifestyle habits.

Published by Medicaldaily.com



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How To Overcome Your Sleep Debt And Reclaim Energy

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Picture this: you’re burning the midnight oil, studying or binge-watching your favorite shows, all at the expense of a good night’s sleep. Have you ever stopped to think about the toll it takes on your body and mind? The consequences can be more serious than you might realize.

Not getting enough sleep can translate into a multitude of issues, including weight gain, lack of focus, tiredness, a haze of confusion, and even depression. If you too are encountering similar issues lately then chances are you have a sleep debt.

Wondering what is sleep debt?

People from 13-18 years of age need 8 hours of sleep, whilst adults beyond that age will require at least 7 hours of snooze.

Sleep debt is a collection of the total hours you haven’t slept or traded your sleep for something else. Sleep debt keeps piling up as a person falls short of the total hours of sleep recommended for an adult, according to the Centers for Disease Control and Prevention.

And when you keep letting go of your sleep for other activities, the body adapts to the new normal and effects start to reflect on the energy levels, which deplete.

“However, like every other debt out there, this too has a repayment option,” Dr. Kunal Kumar, medical director of the Sleep Center at Einstein Medical Center in Philadelphia, told Livestrong.

Below are some expert-vetted ways you can pay back the sleep debt. (Courtesy: Livestrong and Sleepfoundation)

Just like financial debt, imagine sleep debt as a debt you owe to your body. It needs to be repaid. The good news is that catching up on sleep is indeed possible.

  • Maintain a set sleep schedule: Overhauling the sleep schedule is a pretty difficult task to achieve, and it’s best to do that gradually. Create a set sleep schedule by making some small changes to your routine. Instead of making abrupt shifts in your bedtime or wake-up time, adjust them gradually by 15 to 30-minute increments.
  • Minimize your gadget usage: Wind down activities and minimize electronic usage before bed to promote better sleep. Relax and prepare for quality sleep by dimming the lights and setting an alarm for 30 minutes to an hour before bed.
  • Reshuffle your sleeping arrangements: Are you finding it hard to get a good night’s sleep due to excessive sweating? Well, here’s a handy solution: consider upgrading to a cooling mattress or opting for cooling sheets. These innovative sleep essentials can help regulate your body temperature, and keep you comfortably cool throughout the night, ensuring a more blissful slumber. Memory foam pillows can work wonders in relieving neck and back discomfort in case you are struggling with backache.
  • Improve the bedroom environment: Create a sleep-friendly bedroom environment by adjusting the temperature for comfort, and blocking out disruptive lights, or noises that might disturb your restful slumber. And if your mattress, pillow, or sheets are worn out or no longer providing the support you need, consider treating yourself to new ones.

Published by Medicaldaily.com



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Omega-3 Fatty Acids Slow The Progression Of Amyotrophic Lateral Sclerosis: Study

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Omega-3 fatty acids are known for a range of health benefits, from promoting brain and heart health to reducing inflammation and protection against several chronic conditions.

In a new study, researchers found that omega-3 acids, especially the type found in foods like flaxseeds, walnuts, chia seeds, canola oil and soybean oil, can slow down the progression of amyotrophic lateral sclerosis (ALS).

It is a debilitating nervous system disease that gradually worsens over time and can be fatal. The condition results in a loss of muscle control and affects the nerve cells in the brain and spinal cord. It is also known as Lou Gehrig’s disease after the baseball player who was diagnosed with it.

The initial symptoms of the disease include muscle weakness, difficulty in walking and hand movements. The symptoms can slowly progress to difficulties with chewing, swallowing, speaking and breathing.

The exact cause of ALS is not known. However, around 10% of people get it from a risk gene passed down from a family member. It is estimated that more than 32,000 people in the U.S. live with the condition.

In the latest study, researchers from Harvard T.H. Chan School of Public Health in Massachusetts evaluated 449 people living with ALS in a clinical trial. The team assessed the severity of their symptoms, the progression of their disease, along with the levels of omega-3 fatty acids in their blood, for 18 months.

The study suggested that alpha-linolenic acid (ALA), a type of omega-3 found in plants, is particularly beneficial in slowing the progression of ALS. The participants with the highest levels of ALA had a 50% reduced risk of death during the study period compared to those with the lowest levels of ALA.

Researchers also found a reduction in death risk in participants who had eicosapentaenoic acid, the type of omega-3 fatty acid found in fatty fish and fish oil, and linoleic acid found in vegetable oils, nuts and seeds.

A previous study conducted by the same team suggested that a diet high in ALA and higher blood levels of the nutrient could reduce the risk of developing the condition.

“In this study, we found that among people living with ALS, higher blood levels of ALA were also associated with a slower disease progression and a lower risk of death within the study period. These findings, along with our previous research suggest that this fatty acid may have neuroprotective effects that could benefit people with ALS,” said Kjetil Bjornevik, the lead author of the study.

Published by Medicaldaily.com



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