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Vitamin D Deficiency Increases Risk Of Premature Death

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Vitamin D Deficiency Increases Risk Of Premature Death


You might want to take your vitamin D levels seriously. A new study has found low vitamin D levels are associated with premature death.

Researchers from the University of South Australia (UniSA ) conducted the study — published in the journal Annals Of Internal Medicine — which found the severity of vitamin D deficiency was closely linked to increased mortality risk.

“While severe vitamin D deficiency is rarer in Australia than elsewhere in the world, it can still affect those who have health vulnerabilities, the elderly, and those who do not acquire enough vitamin D from healthy sun exposure and dietary sources,” first author, Josh Sutherland, and a Ph.D. student at UniSA, said, reported SciTechDaily.

Vitamin D is an essential nutrient needed by the body to ensure good, healthy bones and muscles.

“Our study provides strong evidence for the connection between low levels of vitamin D and mortality, and this is the first study of its kind to also include respiratory disease-related mortality as an outcome,” Sutherland continued. “We used a new genetic method to explore and affirm the non-linear relationships that we’ve seen in observational settings, and through this, we’ve been able to give strong evidence for the connection between low vitamin D status and premature death.” 

Speaking of challenges in conducting efficient studies on the relation between vitamin D and death risk, Sutherland said, “Vitamin D deficiency has been connected with mortality, but as clinical trials have often failed to recruit people with low vitamin D levels – or have been prohibited from including vitamin deficient participants – it’s been challenging to establish causal relationships.”

For the study, the researchers scrutinized 307,601 records from the UK Biobank, which has participants recruited between March 2006 and July 2010.

Vitamin D levels less than

Senior investigator and Director of UniSA’s Australian Centre for Precision Health, Professor Elina Hyppönen, said more research will help inform public health strategies, which, in turn, will help formulate national guidelines.

“The take-home message here is simple – the key is in the prevention. It is not good enough to think about vitamin D deficiency when already facing life-challenging situations when early action could make all the difference,” Hyppönen said. “It is very important to continue public health efforts to ensure the vulnerable and elderly maintain sufficient vitamin D levels throughout the year.”

Another vitamin, B3, is in the news. A study has found the vitamin B3 supplement nicotinamide riboside (NR), promoted as an anti-aging product, may increase cancer risk and brain metastasis.

“Some people take them [vitamins and supplements] because they automatically assume that vitamins and supplements only have positive health benefits, but very little is known about how they actually work,” co-author Elena Goun explained. “Because of this lack of knowledge, we were inspired to study the basic questions surrounding how vitamins and supplements work in the body.”





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More Mpox Cases Reported In New York, Other States Amid Possible Resurgence

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How To Protect Yourself Against Monkeypox Amid Global Outbreak


More cases of mpox infection have been reported recently, with the U.S. Centers for Disease Control and Prevention (CDC) updating its tally to include 21 more from different locations in the country.

The latest CDC update released Thursday showed that Illinois had recorded nine new cases. On the other hand, New York and Maryland reported three each. Meanwhile, Alabama, Arizona, Florida, Louisiana, Texas, Utah and Virginia had one new case each.

The CDC’s U.S. map and case count also showed that the total number of cases reported in the country since data became available was 30,422. The total number of deaths due to the virus was 42.

Earlier this month, the World Health Organization (WHO) declared the mpox outbreak officially over after recording an almost 90% decline in global cases in the past three months.

However, around the same time, local health officials sounded the alarm over an mpox outbreak in the Chicago area. Between April 17 and May 5, the area reported 12 confirmed and one probable case of mpox infection. All of them were men, and most of them had been vaccinated.

The outbreak prompted the CDC to issue a public health warning about a possible resurgence of mpox in the country this summer, especially when many people gather for festivals and other events.

The CDC also recommended the JYNNEOS vaccine for smallpox and mpox – formerly monkeypox. Though most of the new cases were reported among vaccinated individuals, the agency stressed the importance of getting the shots.

“Getting vaccinated is still very important. No vaccine is 100% effective, and infections after vaccination are possible, but they may be milder and less likely to result in hospitalization,” the CDC stated.

The U.S. still averages less than three cases reported per day, far smaller than the hundreds reported last summer, according to CBS News.

But Dr. Christopher Braden, the head of the CDC’s mpox response, told clinicians in a recent call that things could change very quickly in the coming months.

“The risk of near-term clusters and outbreaks is substantial, and the outbreaks could be large, especially in the warmer months, with planned gatherings that may have the potential for skin-to-skin contact and increased sexual activity,” Braden was quoted as saying by the outlet.

Published by Medicaldaily.com



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COVID-19 Vaccine Fall Overhaul: What You Need To Know

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The COVID-19 pandemic may be a thing of the past now, but the risk of catching the viral disease remains. And so, pharmaceutical companies are still hard at work in delivering vaccine and booster supplies wherever needed.

In the U.S., regulators have already settled on a new strategy for vaccination that would require yearly updated shots, similar to how the flu shot is rolled out every fall season, according to Science.

The U.S. Food and Drug Administration advisers are reportedly convening on June 15 to discuss the next iteration of the COVID-19 vaccine and which strains of the virus it should target. From there, the agency would then greenlight a version that pharmaceutical companies will mass-produce ahead of its fall release.

Earlier this week, Pfizer and Moderna relayed their plan via CNBC to make new versions of their vaccines that would aim to provide broader and longer-lasting immunity against SARS-CoV-2 infection instead of the regularly updated boosters.

The new versions would be ideal in the post-pandemic era since they would simplify how people coexist and deal with the risk of catching the virus annually. The yearly dose pattern works well for the flu, so companies want to do the same with their COVID-19 vaccines.

Interestingly, instead of getting two separate shots each fall season — one for the flu and the other for COVID-19, Pfizer and Moderna plan to release vaccines with a dual purpose. Not only would they be capable of protecting against COVID-19, but they could also target other respiratory diseases, such as the flu.

Both Pfizer and Moderna are working on new vaccines that target both COVID-19 and the flu. Pfizer is also developing another shot that targets both COVID-19 and RSV. However, these dual-purpose vaccines are unlikely to become available until 2024 to 2025.

For this fall season, the goal is to kickstart the planned annual COVID-19 vaccines. This way, people, especially the immunocompromised, won’t have to worry about getting jabbed every three months or so.

Last week, the World Health Organization (WHO) issued a statement on the antigen composition of the COVID-19 vaccines, saying pharmaceutical companies should design updates that no longer target the original strain of SARS-CoV-2 since it is no longer circulating in humans.

In the same breath, the organization shared that its advisory group recommended having a single-strain fall vaccine for the XBB.1 lineage, which is currently dominating across continents. However, the WHO maintained that it’s open to other formulations as long as they enhance mucosal immunity for improved protection against COVID-19 in the post-pandemic era.

Published by Medicaldaily.com



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Those Who Skipped Updated Booster Have ‘Little’ Protection Against COVID-19: Report

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The hesitancy to get the updated COVID-19 booster has put many adults in the U.S. in danger of catching the viral disease.

The latest Morbidity and Mortality Weekly Report from the Centers for Disease Control and Prevention (CDC) pointed out the “relatively little” protection vaccinated adults have after skipping the bivalent booster shots.

According to the CDC, the bivalent mRNA vaccine boosters from Pfizer and Moderna provide protection against COVID-19. However, the durability of such protection was unknown, so it determined the estimated durability of the boosters in preventing COVID-associated hospitalization and critical illness.

The public health agency found that the bivalent booster vaccine effectiveness against COVID-associated hospitalization dropped from 62% at 7-59 days postvaccination to 24% at 120-179 days in adults aged 18 and above without immunocompromising conditions. This is compared to unvaccinated adults.

Among immunocompromised adults, booster vaccine effectiveness was observed against COVID-associated outcomes, including intensive care unit admission or death.

“Adults should stay up to date with recommended COVID-19 vaccines. Optional additional bivalent vaccine doses are available for older adults and persons with immunocompromising conditions,” the CDC wrote.

“Results of this analysis indicate that these adults might have relatively little remaining protection against COVID-19-associated hospitalization compared with unvaccinated persons, although might have more remaining protection against critical illness,” the agency added.

When the bivalent booster shots rolled out last September, experts were hoping for a better uptake than just 20% of U.S. adults as of May 10, according to U.S. News & World Report.

Last month, the Food and Drug Administration (FDA) authorized additional booster shots for people deemed vulnerable to severe COVID-19 illness, including those aged 65 and above and the immunocompromised.

Federal officials are reportedly considering a fall booster campaign to drive more adults to get the updated mRNA vaccine boosters.

Published by Medicaldaily.com



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